vestiagИзвестия Национальной академии наук Беларуси. Серия аграрных наукProceedings of the National Academy of Sciences of Belarus. Agrarian Series1817-72041817-7239The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1817-7204-2024-62-1-57-67vestiag-740Research ArticleЖЫВЁЛАГАДОЎЛЯ І ВЕТЭРЫНАРНАЯ МЕДЫЦЫНАANIMAL HUSBANDRY AND VETERINARY MEDICINEВыявление молекулярных маркеров и генов-кандидатов породной принадлежности северокавказских мясо-шерстных овец методом полногеномного поиска ассоциацийGenome-wide search for associations method for identification of molecular markers and candidate genes of breed affiliation of sheep of the North Caucasian meat and wool breedhttps://orcid.org/0000-0003-0130-3639КриворучкоА. Ю.KrivoruchkoA. Yu.

Криворучко Александр Юрьевич – доктор биологических наук, главный научный сотрудник лаборатории геномной селекции и репродуктивной криобиологии в животноводстве; профессор базовой кафедры генетики и селекции медико-биологического факультета

ул. Никонова, 49, 356241, Михайловск, Ставропольский край, Российская Федерация

ул. Пушкина, 1, 355017, Ставрополь, Российская Федерация

 

Alexander Yu. Krivoruchko – D. Sc. (Biology), Chief Researcher at the Laboratory for Genomic Selection and Reproductive Cryobiology in Animal Husbandry; Professor of the Basic Department of Genetics and Breeding of the Faculty of Biomedical Sciences

49, Nikonova Str., 356241, Mikhailovsk, Stavropol Region, Russian Federation

1, Pushkin Str., 355017, Stavropol, Russian Federation

rcvm@yandex.ruhttps://orcid.org/0000-0002-2193-7498СкоковаА. В.SkokovaA. V.

Скокова Антонина Владимировна – кандидат биологических наук, старший научный сотрудник лаборатории геномной селекции и репродуктивной криобиологии в животноводстве

ул. Никонова, 49, 356241, Михайловск, Ставропольский край, Российская Федерация

Antonina V. Skokova – Ph. D. (Biology), Senior Researcher at the Laboratory for Genomic Selection and Reproductive Cryobiology in Animal Husbandry

49, Nikonova Str., 356241, Mikhailovsk, Stavropol Region, Russian Federation

antoninaskokova@mail.ruhttps://orcid.org/0000-0003-2730-2482ЯцыкО. А.YatsykO. A.

Яцык Олеся Андреевна – кандидат биологических наук, научный сотрудник лаборатории геномной селекции и репродуктивной криобиологии в животноводстве; преподаватель базовой кафедры генетики и селекции медико-биологического факультета

ул. Никонова, 49, 356241, Михайловск, Ставропольский край, Российская Федерация

ул. Пушкина, 1, 355017, Ставрополь, Российская Федерация

Olesya A. Yatsyk – Ph. D. (Biology), Researcher at the Laboratory for Genomic Selection and Reproductive Cryobiology in Animal Husbandry; lecturer of the Basic Department of Genetics and Breeding of the Faculty of Biomedical Sciences

49, Nikonova Str., 356241, Mikhailovsk, Stavropol Region, Russian Federation

1, Pushkin Str., 355017, Stavropol, Russian Federation

malteze@mail.ruhttps://orcid.org/0000-0003-4093-5807КухарукМ. Ю.KuharukM. Yu.

Кухарук Максим Юрьевич – кандидат биологических наук, исполняющий обязанности заведующего кафедрой эволюционной экологии и биоразнообразия

ул. Кулакова, 2, 355000, Ставрополь, Российская Федерация

Maxim Yu. Kuharuk – Ph. D. (Biology), Acting Head of the Department of Evolutionary Ecology and Biodiversity

2, Kulakov Str., 355000, Stavropol, Russian Federation

mkukharuk@ncfu.ruhttps://orcid.org/0000-0002-2190-301XЛиховидА. А.LikhovidA. A.

Лиховид Андрей Александрович – доктор географических наук, профессор, проректор по научной работе

ул. Пушкина, 1, 355017, Ставрополь, Российская Федерация

Andrey A. Likhovid – D. Sc. (Geography), Professor, Vice-Rector for Scientific Work

1, Pushkin Str., 355017, Stavropol, Russian Federation

alikhovid@ncfu.ruhttps://orcid.org/0000-0003-1590-1891КизиловаН. И.KizilovaN. I.

Кизилова Наталья Игоревна – кандидат филологических наук, доцент кафедры иностранных языков

пер. Зоотехнический, 12, 355017, Ставрополь, Российская Федерация

Natalia I. Kizilova – Ph. D. (Philology), Associate Professor of the Department of Foreign Languages

12, Zootechnicheckiy lane, 355017, Stavropol, Russian Federation

natali0403_87@mail.ruСеверо-Кавказский федеральный научный аграрный центр; Северо-Кавказский федеральный университетNorth Caucasus Federal Agrarian Research Center; North Caucasus Federal UniversityСеверо-Кавказский федеральный научный аграрный центрNorth Caucasus Federal Agrarian Research CenterСеверо-Кавказский федеральный университетNorth Caucasus Federal UniversityСтавропольский государственный аграрный университетStavropol State Agrarian University2024100220246215767Copyright © Криворучко А.Ю., Скокова А.В., Яцык О.А., Кухарук М.Ю., Лиховид А.А., Кизилова Н.И., 20242024Криворучко А.Ю., Скокова А.В., Яцык О.А., Кухарук М.Ю., Лиховид А.А., Кизилова Н.И.Krivoruchko A.Y., Skokova A.V., Yatsyk O.A., Kuharuk M.Y., Likhovid A.A., Kizilova N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestiagr.belnauka.by/jour/article/view/740

Выполнен полногеномный поиск ассоциаций однонуклеотидных полиморфизмов (SNP) с принадлежностью баранов к северокавказской мясо-шерстной породе. Для этого проведено генотипирование 275 голов овец российских пород с использованием ДНК-биочипов компании Illumina и детекцией 600 тыс. SNP. Группа «случай» была представлена животными северокавказской мясо-шерстной породы (n = 55), в группу «контроль» вошли животные таких пород, как карачаевская, романовская, джалгинский меринос и российский мясной меринос (по 55 голов каждой породы). В результате исследования было выявлено более 100 SNP с высокодостоверными различиями по частоте встречаемости (–log10(p) > 7) у овец северокавказской мясо-шерстной породы и пород сравнения. Для поиска генов-кандидатов породной принадлежности было отобрано 18 полиморфизмов с наиболее высокими показателями достоверности, локализованные на хромосомах 1, 10, 11, 15, 17. В пределах половины сантиморганиды от них было обнаружено одиннадцать генов: DEPDC1, RXFP2, EEF1A1, B3GLCT, FAM124A, FNDC3A, SLC25A5, CAMTA2, NLRP1, ALX4, TMEM132C. Эти гены мы считаем перспективными для дальнейшего изучения с целью поиска структурных особенностей, связанных с фенотипом северокавказской мясо-шерстной породы. Выявленные нами SNP могут быть использованы для молекулярно-генетической экспертизы при оценке породной принадлежности животных.

To determine the loci associated with pedigree traits, a genome-wide search was conducted for associations of 275 heads of Russian sheep breeds genotyped using 600 thousand single nucleotide polymorphisms (SNPs). The studies were conducted according to the “case-control” type, where the “case” group is represented by animals of the North Caucasian meat and wool breed, the “control” included animals of other breeds (Karachay, Romanovskaya, Dzhalginsky merino and Russian meat merino). In this study, over 100 SNPs were identified with highly reliable differences in the frequency of occurrence in sheep of the North Caucasian meat and wool breed. For the subsequent analysis, 18 single nucleotides with the highest confidence indices localized on chromosomes were selected 1, 10, 11, 15, 17. As a result of a genome-wide study, significant SNP markers characteristic of the sheep breed under study, located directly in the genes or close to them, were determined. The conducted studies provide a set of new SNP markers and candidate genes associated with the breed characteristics of North Caucasian meat-wool sheep.

овцыидентификация породыоднонуклеотидный полиморфизмДНК-биочипполногеномный поиск ассоциацийsheepbreed identificationsingle nucleotide polymorphismDNA biochipgenome-wide association searchReferencesCharacteristics of gene pool of various sheep breeds of the Republic of Kazakhstan / Z. Iskakova [et al.] // EurAsian J. Biosci. – 2020. – Vol. 14, № 1. – P. 2395–2402.Iskakova Z., Alibayev N., Burabaev A., Yessirkepov M., Marzanov N. Characteristics of gene pool of various sheep breeds of the Republic of Kazakhstan. EurAsian Journal of BioSciences, 2020, vol. 14, no. 1, pp. 2395–2402.Методология управления формированием функционально-технологических свойств животноводческого сырья за счет оптимизации селекционных и паратипических факторов / М. И. Сложенкина [и др.] // Аграр.-пищевые инновации. – 2018. – № 2 (2). – С. 6–15. https://doi.org/10.31208/2618-7353-2018-1-2-6-15Slozhenkina M. I., Gorlov I. F., Randelin A. V., Mosolov A. A., Zlobina E. Yu., Knyazhechenko O. A., Garyaeva H. B., Mosolova D. A. Methodology for management of formation functional-technological properties of raw materials of animal origin in the account of optimization of selection and parapypic factors. Agrarno-pishchevye innovatsii = Agrarian-and-Food Innovations, 2018, no. 2 (2), pp. 6–15 (in Russian). https://doi.org/10.31208/2618-7353-2018-1-2-6-15On the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis tools / E. Ciani [et al.] // Genet. Sel. Evol. – 2020. – Vol. 52. – Art. 25. https://doi.org/10.1186/s12711-020-00545-7Ciani E., Mastrangelo S., Da Silva A., Marroni F., Ferenčaković M., Ajmone-Marsan P. [et al.]. On the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis tools. Genetics Selection Evolution, 2020, vol. 52, art. 25. https://doi.org/10.1186/s12711-020-00545-7Генетическая изменчивость казахской полугрубошерстной породы овец / Н. Ж. Каримов [и др.] // Вестн. Кыргыз. нац. аграр. ун-та им. К. И. Скрябина. – 2020. – № 1 (52). – С. 17–21.Karimov N. Zh., Chortonbaev T. Zh., Bekturov A. B., Zholborsov U. K. Genetic variability of the Kazakh semi-sheep-haired breed sheep. Vestnik Kyrgyzskogo natsional’nogo agrarnogo universiteta im. K. I. Skryabina = Vestnik of the Kyrgyz National Agrarian University K. I. Scriabin, 2020, no. 1 (52), pp. 17–21 (in Russian).Mihailova, Y. Genetic diversity and structure of 2 indigenous sheep breeds (Kotel and Teteven) in Bulgaria using microsatellite markers / Y. Mihailova // Biotechnol. Biotechnol. Equip. – 2021. – Vol. 35, № 1. – P. 576–585. https://doi.org/10.1080/13102818.2021.1903339Mihailova Y. Genetic diversity and structure of 2 indigenous sheep breeds (Kotel and Teteven) in Bulgaria using microsatellite markers. Biotechnology & Biotechnological Equipment, 2021, vol. 35, no. 1, pp. 576–585. https://doi.org/10.1080/13102818.2021.1903339Иммунологические, генетические и биологические маркеры в селекции овец и коз / Н. С. Марзанов [и др.] // Молекулярно-генетические технологии для анализа экспрессии генов продуктивности и устойчивости к заболеваниям животных: материалы 2-й Междунар. науч.-практ. конф., 25 дек. 2020 г. / Моск. гос. акад. ветеринар. медицины и биотехнологии; редкол.: И. И. Кочиш [и др.]. – М., 2020. – С. 249–258.Marzanov N. S., Devrishov D. A., Feizullaev F. R., Marzanova S. N., Koreckaja E. A. Immunological, genetic and biological markers in sheep and goat breeding. Molekulyarno-geneticheskie tekhnologii dlya analiza ekspressii genov produktivnosti i ustoichivosti k zabolevaniyam zhivotnykh: materialy 2-i Mezhdunarodnoi nauchno-prakticheskoi konferentsii, 25 dekabrya 2020 g. [Molecular genetic technologies for analysis of gene expression related to animal productivity and disease resistance: proceedings of the 2nd international scientific and practical conference, December 25, 2020]. Moscow, 2020, pp. 249–258 (in Russian).Изменчивость микросателлитов в породах овец, разводимых в России / Т. Е. Денискова [и др.] // С.-х. биология. – 2016. – Т. 51, № 6. – С. 801–810. https://doi.org/10.15389/agrobiology.2016.6.801rusDeniskova T. E., Selionova M. I., Gladyr’ E. A., Dotsev A. V., Bobryshova G. T., Kostyunina O. V., Brem G., Zino-Evaluation of single nucleotide polymorphisms identified through the use of SNP assay in Romanian and Chinese Holstein and Simmental cattle breeds / D. E. Ilie [et al.] // Acta Biochim. Pol. – 2020. – Vol. 67, № 3. – P. 341–346. https://doi.org/10.18388/ABP.2020_5080vieva N. A. Variability of microsatellites in sheep breeds raced in Russia. Sel’skokhozyaistvennaya biologiya = Agricultural Biology, 2016, vol. 51, no. 6, pp. 801–810 (in Russian). https://doi.org/10.15389/agrobiology.2016.6.801rusWhole-genome resequencing shows numerous genes with nonsynonymous SNPs in the Japanese native cattle Kuchinoshima­Ushi / R. Kawahara-Miki [et al.] // BMC Genom. – 2011. – Vol. 12. – Art. 103. https://doi.org/10.1186/1471-2164-12-103Ilie D. E., Gao Y., Nicolae I., Sun D., Li J., Han B., Gavojdian D. Evaluation of single nucleotide polymorphisms identified through the use of SNP assay in Romanian and Chinese Holstein and Simmental cattle breeds. Acta Biochimica Polonica, 2020, vol. 67, no. 3, pp. 341–346. https://doi.org/10.18388/ABP.2020_5080Whole-genome sequence-based genomic prediction in laying chickens with different genomic relationship matrices to account for genetic architecture / G. Ni [et al.] // Genet. Sel. Evol. – 2017. – Vol. 49. – Art. 8. https://doi.org/10.1186/s12711-016-0277-yKawahara-Miki R., Tsuda K., Shiwa Y., Arai-Kichise Y., Matsumoto T., Kanesaki Y., Oda S.-I., Ebihara S., Yajima S., Yoshikawa H., Kono T. Whole-genome resequencing shows numerous genes with nonsynonymous SNPs in the Japanese native cattle Kuchinoshima-Ushi. BMC Genomics, 2011, vol. 12, art. 103. https://doi.org/10.1186/1471-2164-12-103Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology / J. Plassais [et al.] // Nat. Commun. – 2019. – Vol. 10. – Art. 1489. https://doi.org/10.1038/s41467-019-09373-wNi G., Cavero D., Fangmann A., Erbe M., Simianer H. Whole-genome sequence-based genomic prediction in laying chickens with different genomic relationship matrices to account for genetic architecture. Genetics Selection Evolution, 2017, vol. 49, art. 8. https://doi.org/10.1186/s12711-016-0277-yЮдин, Н. С. Общие признаки селекции и гены, связанные с адаптацией и акклиматизацией, в геномах российских пород крупного рогатого скота и овец / Н. С. Юдин, Д. М. Ларкин // Генетика. – 2019. – Т. 55, № 8. – С. 936–943. https://doi.org/10.1134/s0016675819070154Plassais J., Kim J., Davis B. W., Karyadi D. M., Hogan A. N., Harris A. C., Decker B., Parker H. G., Ostrander E. A. Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology. Nature Communications, 2019, vol. 10, art. 1489. https://doi.org/10.1038/s41467-019-09373-wDevelopment and application of high-density SNP arrays in genomic studies of domestic animals / B. Fan [et al.] // Asian-Australas. J. Anim. Sci. – 2010. – Vol. 23, № 7. – P. 833–847. https://doi.org/10.5713/ajas.2010.r.03Yudin N., Larkin D. M. Shared signatures of selection related to adaptation and acclimation in local cattle and sheep breeds from Russia. Russian Journal of Genetics, 2019, vol. 55, no. 8, pp. 1008–1014. https://doi.org/10.1134/s1022795419070159Оценка биоразнообразия межвидовых гибридов рода Ovis с использованием STR- и SNP-маркеров / Т. Е. Денискова [и др.] // С.-х. биология. – 2017. – Т. 52, № 2. – С. 251–260. https://doi.org/10.15389/agrobiology.2017.2.251rusFan B., Du Z. Q., Gorbach D. M., Rothschild M. F. Development and application of high-density SNP arrays in genomic studies of domestic animals. Asian-Australasian Journal of Animal Sciences, 2010, vol. 23, no. 7, pp. 833–847. https://doi.org/10.5713/ajas.2010.r.03Генетические маркеры в козоводстве (обзор) / М. И. Селионова [и др.] // С.-х. биология. – 2021. – Т. 56, № 6. – С. 1031–1048. https://doi.org/10.15389/agrobiology.2021.6.1031rusDeniskova T. E., Dotsev A. V., Bagirov V. A., Wimmers K., Reyer H., Brem G., Zinovieva N. A. Biodiversity assessment in interspecies hybrids of the genus Ovis using STR and SNP markers. Sel’skokhozyaistvennaya biologiya = Agricultural Biology, 2017, vol. 52, no. 2, pp. 251–260 (in Russian). https://doi.org/10.15389/agrobiology.2017.2.251rusGenome-wide selection of discriminant SNP markers for breed assignment in indigenous sheep breeds / M. H. Moradi [et al.] // Ann. Anim. Sci. – 2021. – Vol. 21, № 3. – P. 807–831. https://doi.org/10.2478/aoas-2020-0097Selionova M. I., Trukhachev V. I., Aybazov A. M. M., Stolpovsky Yu. A., Zinovieva N. A. Genetic markers of goats (review). Sel’skokhozyaistvennaya biologiya = Agricultural Biology, 2021, vol. 56, no. 6, pp. 1031–1048 (in Russian). https://doi.org/10.15389/agrobiology.2021.6.1031rusОмаров, А. А. Продуктивные показатели овец северокавказской мясо-шерстной породы и их взаимосвязь с основными селекционируемыми признаками / А. А. Омаров, С. И. Гайдашов // Вестн. Алт. гос. аграр. ун-та. – 2021. – № 2 (196). – С. 66–72.Moradi M. H., Khaltabadi-Farahani A. H., Khodaei-Motlagh M., Kazemi-Bonchenari M., McEwan J. Genome-wide selection of discriminant SNP markers for breed assignment in indigenous sheep breeds. Annals of Animal Science, 2021, vol. 21, no. 3, pp. 807–831. https://doi.org/10.2478/aoas-2020-0097PLINK: a tool set for whole-genome association and population-based linkage analyses / S. Purcell [et al.] // Am. J. Hum. Genet. – 2007. – Vol. 81, № 3. – P. 559–575. https://doi.org/10.1086/519795Omarov A. A., Gaidashov S. I. Productive indicators of sheep of the North Caucasian meat and wool breed and their relationship with the main selected traits. Vestnik Altaiskogo gosudarstvennogo agrarnogo universiteta = Bulletin of Altai State Agrarian University, 2021, no. 2 (196), pp. 66–72 (in Russian).Shen, X. Overexpression of gene DEP domain containing 1 and its clinical prognostic significance in colorectal cancer / X. Shen, J. Han // J. Clin. Lab. Anal. – 2020. – Vol. 34, № 12. – P. e23634. https://doi.org/10.1002/jcla.23634Purcell S., Neale B., Todd-Brown K., L. Thomas, Ferreira M. A. R., Bender D., Maller J., Sklar P., De Bakker P. I. W., Daly M. J., Sham P. C. PLINK: a tool set for whole-genome association and population-based linkage analyses. American Society of Human Genetics, 2007, vol. 81, no. 3, pp. 559–575. https://doi.org/10.1086/519795The eukaryotic elongation factor eEF1A1 interacts with SAMHD1 / C. Morrissey [et al.] // Biochem. J. – 2015. – Vol. 466, № 1. – P. 69–76. https://doi.org/10.1042/BJ20140203Shen X., Han J. Overexpression of gene DEP domain containing 1 and its clinical prognostic significance in colorectal cancer. Journal of Clinical Laboratory Analysis, 2020, vol. 34, no. 12, p. e23634. https://doi.org/10.1002/jcla.23634Expression analysis of solute carrier (SLC2A) genes in milk derived mammary epithelial cells during different stages of lactation in sahiwal (Bos indicus) cows / J. Pradeep [et al.] // Adv. Dairy Res. – 2014. – Vol. 2. – Art. 2. https://doi.org/10.4172/2329-888X.1000117Morrissey C., Schwefel D., Ennis-Adeniran V., Taylor I. A., Crow Y. J., Webb M. The eukaryotic elongation factor eEF1A1 interacts with SAMHD1. Biochemical Journal, 2015, vol. 466, no. 1, pp. 69–76. https://doi.org/10.1042/BJ20140203Krivoruchko A. Y. Candidate genes for productivity identified by genome-wide association study with indicators of class in the Russian meat merino sheep breed / A. Y. Krivoruchko, O. A. Yatsyk, E. Y. Safaryan // Вавил. журн. генетики и селекции. – 2020. – Т. 24, № 8. – С. 836–843. https://doi.org/10.18699/VJ20.681Pradeep J., Monika S., Ankita S., Umesh K. S., Amit K., Ashok M., Mishra B. P., Sandeep M., Kataria R. S., Kaushik J., Mukesh M. Expression analysis of solute carrier (SLC2A) genes in milk derived mammary epithelial cells during different stages of lactation in sahiwal (Bos indicus) cows. Advances in Dairy Research, 2014, vol. 2, art. 2. https://doi.org/10.4172/2329-888X.1000117Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation / R. C. K. Kong [et al.] // Biochemistry. – 2014. – Vol. 53, № 28. – P. 4537–4548. https://doi.org/10.1021/bi500797dKrivoruchko A. Y., Yatsyk O. A., Safaryan E. Y. Candidate genes for productivity identified by genome-wide association study with indicators of class in the Russian meat merino sheep breed. Vavilovskii zhurnal genetiki i selektsii = Vavilov Journal of Genetics and Breeding, 2021, vol. 24, no. 8, pp. 836–843. https://doi.org/10.18699/VJ20.681Discovery of SNPs in RXFP2 related to horn types in sheep / X. Wang [et al.] // Small Rumin. Res. – 2014. – Vol. 116, № 2–3. – P. 133–136. https://doi.org/10.1016/j.smallrumres.2013.10.022Kong R. C. K., Bathgate R. A. D., Bruell S., Wade J. D., Gooley P. R., Petrie E. J. Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation. Biochemistry, 2014, vol. 53, no. 28, pp. 4537–4548. https://doi.org/10.1021/bi500797dRuns of homozygosity and signatures of selection: a comparison among eight local Swiss sheep breeds / H. SignerHasler [et al.] // Anim. Genet. – 2019. – Vol. 50, № 5. – P. 512–525. https://doi.org/10.1111/age.12828Wang X., Zhou G., Li Q., Zhao D., Chen Y. Discovery of SNPs in RXFP2 related to horn types in sheep. Small Ruminant Research, 2014, vol. 116, no. 2–3, pp. 133–136. https://doi.org/10.1016/j.smallrumres.2013.10.022Murine ortholog of the novel glycosyltransferase, B3GTL: primary structure, characterization of the gene and transcripts, and expression in tissues / T. Y. K. Heinonen [et al.] // DNA Cell Biol. – 2006. – Vol. 25, № 8. – P. 465–474. https://doi.org/10.1089/dna.2006.25.465Signer-Hasler H., Burren A., Ammann P., Drögemüller C., Flury C. Runs of homozygosity and signatures of selection: a comparison among eight local Swiss sheep breeds. Animal Genetics, 2019, vol. 50, no. 5, pp. 512–525. https://doi.org/10.1111/age.12828Molecular cloning and characterization of a novel human β1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain / T. Sato [et al.] // Glycobiology. – 2006. – Vol. 16, № 12. – P. 1194–1206. https://doi.org/10.1093/glycob/cwl035Heinonen T. Y. K., Pelto-Huikko M., Pasternack L., Mäki M., Kainulainen H. Murine ortholog of the novel glycosyltransferase, B3GTL: primary structure, characterization of the gene and transcripts, and expression in tissues. DNA and Cell Biology, 2006, vol. 25, no. 8, pp. 465–474. https://doi.org/10.1089/dna.2006.25.465A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in nordic red cattle: additional evidence for the common occurrence of balancing selection in livestock / N. K. Kadri [et al.] // PLoS Genet. – 2014. – Vol. 10, № 1. – P. e1004049. https://doi.org/10.1371/journal.pgen.1004049Sato T., Sato M., Kiyohara K., Sogabe M., Shikanai T., Kikuchi N. [et al.]. Molecular cloning and characterization of a novel human β1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain. Glycobiology, 2006, vol. 16, no. 12, pp. 1194–1206. https://doi.org/10.1093/glycob/cwl035Expression analysis of fibronectin type III domain-containing (FNDC) genes in inflammatory bowel disease and colorectal cancer / T. Wuensch [et al.] // Gastroenterol. Res. Pract. – 2019. – Vol. 2019. – Art. 3784172. https://doi.org/10.1155/2019/3784172Kadri N. K., Sahana G., Charlier C., Iso-Touru T., Guldbrandtsen B., Karim L. [et al.]. A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in nordic red cattle: additional evidence for the common occurrence of balancing selection in livestock. PLoS Genetics, 2014, vol. 10, no. 1, p. e1004049. https://doi.org/10.1371/journal.pgen.1004049Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells / S. Zhu [et al.] // Cell. Mol. Biol. Lett. – 2022. – Vol. 27. – Art. 11. https://doi.org/10.1186/s11658-022-00314-yWuensch T., Wizenty J., Quint J., Spitz W., Bosma M., Becker O. [et al.]. Expression analysis of fibronectin type III domain-containing (FNDC) genes in inflammatory bowel disease and colorectal cancer. Gastroenterology Research and Practice, 2019, vol. 2019, art. 3784172. https://doi.org/10.1155/2019/3784172A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription / W.-H. Song [et al.] // J. Hypertens. – 2016. – Vol. 34, № 5. – P. 942–949. https://doi.org/10.1097/HJH.0000000000000873Zhu S., Wang W., Zhang J., Ji S., Jing Z., Chen Y. Q. Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells. Cellular & Molecular Biology Letters, 2022, vol. 27, art. 11. https://doi.org/10.1186/s11658-022-00314-yGermline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation / F. L. Zhong [et al.] // Cell. – 2016. – Vol. 167. – P. 187–202. https://doi.org/10.1016/j.cell.2016.09.001Song W., Lin Y., Sun K., Zhang Y., Song Y., Hou L., Zhang C., Hui R., Chen J. A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription. Journal of Hypertension, 2016, vol. 34, no. 5, pp. 942–949. https://doi.org/10.1097/HJH.0000000000000873Variants in ALX4 and their association with genitourinary defects / C. H. Chen [et al.] // Andrology. – 2020. – Vol. 8, № 5. – P. 1243–1255. https://doi.org/10.1111/andr.12815Zhong F. L., Mamaï O., Sborgi L., L. Boussofara, R. Hopkins, K. Robinson [et al.]. Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation. Cell, 2016, vol. 167, pp. 187–202. https://doi.org/10.1016/j.cell.2016.09.001Linkage and association of childhood asthma with the chromosome 12 genes / C. Shao [et al.] // J. Hum. Genet. – 2004. – Vol. 49, № 3. – P. 115–122. https://doi.org/10.1007/s10038-003-0118-zChen C. H., Bournat J. C., Wilken N., Rosenfeld J. A., Zhang J., Seth A., Jorgez C. J. Variants in ALX4 and their association with genitourinary defects. Andrology, 2020, vol. 8, no. 5, pp. 1243–1255. https://doi.org/10.1111/andr.12815Four genetic loci affecting swine lung lesions identified by whole-genome sequencing-based association studies / X. Tong [et al.] // Sci. China Life Sci. – 2021. – Vol. 64, № 9. – P. 1571–1574. https://doi.org/10.1007/s11427-020-1826-xShao C., Suzuki Y., Kamada F., Kanno K., Tamari M., Hasegawa K. [et al.]. Linkage and association of childhood asthma with the chromosome 12 genes. Journal of Human Genetics, 2004, vol. 49, no. 3, pp. 115–122. https://doi.org/10.1007/s10038-003-0118-zWhole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed / H. Moradian [et al.] // Genes Genom. – 2020. – Vol. 42, № 2. – P. 203–215. https://doi.org/10.1007/s13258-019-00888-6Tong X., Huang T., Zhang M., Chen J., Zhang Z., Li J. [et al.]. Four genetic loci affecting swine lung lesions identified by whole-genome sequencing-based association studies. Science China Life Sciences, 2021, vol. 64, no. 9, pp. 1571–1574. https://doi.org/10.1007/s11427-020-1826-xMoradian H., Esmailizadeh Koshkoiyeh A., Mohammadabadi M., Asadi Fozi M. Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed. Genes & Genomics, 2020, vol. 42, no. 2, pp. 203–215. https://doi.org/10.1007/s13258-019-00888-6Moradian H., Esmailizadeh Koshkoiyeh A., Mohammadabadi M., Asadi Fozi M. Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed. Genes & Genomics, 2020, vol. 42, no. 2, pp. 203–215. https://doi.org/10.1007/s13258-019-00888-6

The authors declare that there are no conflicts of interest present.