<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestiag</journal-id><journal-title-group><journal-title xml:lang="ru">Известия Национальной академии наук Беларуси. Серия аграрных наук</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of the National Academy of Sciences of Belarus. Agrarian Series</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1817-7204</issn><issn pub-type="epub">1817-7239</issn><publisher><publisher-name>The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29235/1817-7204-2023-61-2-141-150</article-id><article-id custom-type="elpub" pub-id-type="custom">vestiag-701</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЖЫВЁЛАГАДОЎЛЯ І ВЕТЭРЫНАРНАЯ МЕДЫЦЫНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANIMAL HUSBANDRY AND VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Гены-маркеры продуктивного долголетия крупного рогатого скота</article-title><trans-title-group xml:lang="en"><trans-title>Marker genes for productive longevity of cattle</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4684-9830</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шейко</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheiko</surname><given-names>I. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шейко Иван Павлович – академик Национальной академии наук Беларуси, доктор сельскохозяйственных наук, профессор</p><p>ул. Фрунзе, 11, 222160, Жодино, Минская обл.</p></bio><bio xml:lang="en"><p>Ivan P. Sheiko – Academician of the National Academy of Sciences of Belarus, D. Sc. (Agriculture), Professor</p><p>11, Frunze Str., 222160, Zhodino, Minsk Region</p></bio><email xlink:type="simple">belniig@tut.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8416-535X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жерносеков</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhernosekov</surname><given-names>D. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жерносеков Дмитрий Данилович – доктор биологических наук, заведующий кафедрой зоологии и ботаники</p><p>пр. Московский, 33, 210038, Витебск</p></bio><bio xml:lang="en"><p>Dmitriy D. Zhernosekov – D. Sc. (Biology), Head of the Department of Zoology and Botany</p><p>33, Moskovsky Ave., 210038, Vitebsk</p></bio><email xlink:type="simple">chemikdd@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирханов</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Pirhanov</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пирханов Гапланг Гадамович – преподаватель кафедры зоологии и ботаники</p><p>пр. Московский, 33, 210038, Витебск</p></bio><bio xml:lang="en"><p>Gaplang G. Pirhanov – Lecturer of the Department of Zoology and Botany </p><p>33, Moskovsky Ave., 210038, Vitebsk</p></bio><email xlink:type="simple">pirhanow1997@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-практический центр Национальной академии наук Беларуси по животноводству</institution></aff><aff xml:lang="en"><institution>Scientific and Practical Center of the National Academy of Sciences of Belarus on Animal Husbandry</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Витебский государственный университет имени П. М. Машерова</institution></aff><aff xml:lang="en"><institution>Vitebsk State University named after P. M. Masherov</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>05</day><month>05</month><year>2023</year></pub-date><volume>61</volume><issue>2</issue><fpage>141</fpage><lpage>150</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шейко И.П., Жерносеков Д.Д., Пирханов Г.Г., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Шейко И.П., Жерносеков Д.Д., Пирханов Г.Г.</copyright-holder><copyright-holder xml:lang="en">Sheiko I.P., Zhernosekov D.D., Pirhanov G.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestiagr.belnauka.by/jour/article/view/701">https://vestiagr.belnauka.by/jour/article/view/701</self-uri><abstract><p>Получение высокопродуктивных сельскохозяйственных животных в молочном скотоводстве с использованием новейших биотехнологических приемов и методов с целью продления их максимального продуктивного долголетия является важнейшей мировой проблемой. Рассмотрены первостепенные задачи, которые стоят перед скотоводческими хозяйствами страны, по разработке и внедрению в практику новых методов биотехнологии и генной инженерии по выявлению генов-маркеров, отвечающих за долголетие высокопродуктивных коров. Излагаются материалы по изучению генетического потенциала животных по хозяйственно полезным признакам: интенсивность роста, молочная продуктивность, воспроизводительные качества, продуктивное долголетие и устойчивость к заболеваниям. Доказано, что этого можно достичь только благодаря целенаправленной селекции и созданию племенной базы. Установлено, что изучение аллельного полиморфизма генов-маркеров долголетия крупного рогатого скота является актуальным направлением в условиях Республики Беларусь. На современном этапе все больше внимания уделяется изучению полиморфизма ДНК-маркеров продуктивных качеств сельскохозяйственных животных. Их использование в качестве методов более объективной оценки племенных достоинств животных может ускорить и стабилизировать управление селекционными процессами. Особое внимание уделено генетической оценке и методам селекции долголетия, которые рассмотрены в научной литературе последнего десятилетия.</p></abstract><trans-abstract xml:lang="en"><p>Obtaining highly productive farm animals in dairy cattle breeding using the latest biotechnological techniques and methods in order to extend their maximum productive life is the most important world problem. This paper sets out the priority tasks for the country’s livestock farms to develop and implement new biotechnology and genetic engineering methods in order to identify the marker genes responsible for the longevity of highly productive cows. Materials on the study of the genetic potential of animals with due consideration of the following economically useful traits are presented – growth intensity, milk productivity, reproductive performance, productive longevity and disease resistance. It has been proven that this can only be achieved through targeted selection and the creation of a breeding base. It has been established that the study of allelic polymorphism of cattle longevity marker genes is a relevant area in the conditions of the Republic of Belarus. At the present stage, more and more attention is being paid to the study of polymorphism of DNA markers of production traits of farm animals. Using them as methods for a more objective assessment of breeding values of animals can accelerate and stabilize the management of selection processes. In the paper, special attention is paid to genetic evaluation and selection methods for longevity, which have been reviewed in the scientific literature of the last decade.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>долголетие коров</kwd><kwd>фертильность</kwd><kwd>методы селекции</kwd><kwd>ДНК-маркеры</kwd><kwd>гены</kwd></kwd-group><kwd-group xml:lang="en"><kwd>longevity of cows</kwd><kwd>fertility rate</kwd><kwd>selection methods</kwd><kwd>DNA markers</kwd><kwd>genes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Связь полиморфизма гена каппа-казеина с молочной продуктивностью коров различных пород / И. П. Шейко [и др.] // Докл. Нац. акад. наук Беларуси. – 2009. – Т. 53, № 5. – С. 113–118.</mixed-citation><mixed-citation xml:lang="en">Sheiko I. P., Tanana L. A., Yepishka T. I., Mostovoi D. E., Piashko V. V., Pestis M. V. Relationship between the polymorphism of the kappa-casein gene and the dairy efficiency of cows of various breeds. Doklady Natsional’noi akademii nauk Belarusi = Doklady of the National Akademy of Sciences of Belarus, 2009, vol. 53, no. 5, pp. 113–118 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Economic costs of recorded reasons for cow mortality and culling in a pasture-based dairy industry / J. I. Kerslake [et al.] // J. Dairy Sci. – 2018. – Vol. 101, № 2. – P. 1795–1803. https://doi.org/ 10.3168/jds.2017-13124</mixed-citation><mixed-citation xml:lang="en">Kerslake J. I., Amer P. R., O’Neil P. L., Wong S. L., Roche J. R., Phyn C. V. C. Economic costs of recorded reasons for cow mortality and culling in a pasture-based dairy industry. Journal of Dairy Science, 2018, vol. 101, no. 2, pp. 1795–1803. https://doi.org/10.3168/jds.2017-13124</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Genetic analysis of productive life length in Holstein dairy cows using Weibull proportional risk model / H. A. Najafabadi [et al.] // Arch. Anim. Breed. – 2016. – Vol. 59, № 3. – P. 387–393. https://doi.org/ 10.5194/aab-59-387-2016</mixed-citation><mixed-citation xml:lang="en">Najafabadi H. A., Mahayari S. A., Edriss M. A., Strapakova E. Genetic analysis of productive life length in Holstein dairy cows using Weibull proportional risk model. Archives Animal Breeding, 2016, vol. 59, no. 3, pp. 387–393. https://doi.org/ 10.5194/aab-59-387-2016</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">De Vries, A. Review: Overview of factors affecting productive lifespan of dairy cows / A. de Vries, M. I. Marcondes // Animal. – 2020. – Vol. 14, № S1. – P. S155–S164. https://doi.org/10.1017/S1751731119003264</mixed-citation><mixed-citation xml:lang="en">De Vries A., Marcondes M. I. Review: Overview of factors affecting productive lifespan of dairy cows. Animal, 2020, vol. 14, no. S1, pp. S155–S164. https://doi.org/10.1017/S1751731119003264</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">A review on longevity trait in dairy cattle breeding / Y. Zhang [et al.] // Sci. Agric. Sin. – 2020. – Vol. 53, № 19. – P. 4070–4082 (на кит. яз.). https://doi.org/10.3864/j.issn.0578-1752.2020.19.019</mixed-citation><mixed-citation xml:lang="en">Zhang H., Liu A., Mi S., Li X., Luo H., Yan X., Wang Y. 奶牛育种中的长寿性状 [A review on longevity trait in dairy cattle breeding]. Scientia Agriculture Sinica, 2020, vol. 53, no. 19, pp. 4070–4082 (in Chinese). https://doi.org/10.3864/j.issn. 0578-1752.2020.19.019</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Invited review: academic and applied approach to evaluating longevity in dairy cows / J. C. Schuster [et al.] // J. Dairy Sci. – 2020. – Vol. 103, № 12. – P. 11008–11024. https://doi.org/10.3168/jds.2020-19043</mixed-citation><mixed-citation xml:lang="en">Schuster J. C., Barkema H. W., De Vries A., Kelton D. F., Orsel K. Invited review: academic and applied approach to evaluating longevity in dairy cows. Journal of Dairy Science, 2020, vol. 103, no. 12, pp. 11008–11024. https://doi.org/10.3168/ jds.2020-19043</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">De Vries, A. Symposium review: why revisit dairy cattle productive lifespan? / A. de Vries // J. Dairy Sci. – 2020. – Vol. 103, № 4. – P. 3838–3845. https://doi.org/10.3168/jds.2019-17361</mixed-citation><mixed-citation xml:lang="en">De Vries A. Symposium review: why revisit dairy cattle productive lifespan? Journal of Dairy Science, 2020, vol. 103, no. 4, pp. 3838–3845. https://doi.org/10.3168/jds.2019-17361</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Impact of longevity on greenhouse gas emissions and profitability of individual dairy cows analysed with different system boundaries / F. Grandl [et al.] // Animal. – 2019. – Vol. 13, № 1. – P. 198–208. https://doi.org/10.1017/S175173111800112X</mixed-citation><mixed-citation xml:lang="en">Grandl F., Furger M., Kreuzer M., Zehetmeier M. Impact of longevity on greenhouse gas emissions and profitability of individual dairy cows analysed with different system boundaries. Animal, 2019, vol. 13, no. 1, pp. 198–208. https://doi.org/ 10.1017/S175173111800112X</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle / S. D. Cochran [et al.] // BMC Genet. – 2013. – Vol. 14. – Art. 49. https://doi.org/10.1186/1471-2156-14-49</mixed-citation><mixed-citation xml:lang="en">Cochran S. D., Cole J. B., Null D. J., Hansen P. J. Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle. BMC Genetics, 2013, vol. 14, art. 49. https://doi.org/10.1186/ 1471-2156-14-49</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows / X. Chen [et al.] // PLoS One. – 2017. – Vol. 12, № 4. – P. e0175555. https://doi.org/10.1371/journal.pone.0175555</mixed-citation><mixed-citation xml:lang="en">Chen X., Zhang S., Cheng Z., Cooke J. S., Werling D., Wathes D. C., Pollott G. E. Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows. PLoS One, 2017, vol. 12, no. 4, p. e0175555. https://doi.org/10.1371/journal.pone.0175555</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">A candidate gene association study for nine economically important traits in Italian Holstein cattle / L. Fontanesi [et al.] // Anim. Genet. – 2014. – Vol. 45, № 4. – P. 576–580. https://doi.org/10.1111/age.12164</mixed-citation><mixed-citation xml:lang="en">Fontanesi L., Calò D. G., Galimberti G., Negrini R., Marino R., Nardone A., Ajmone-Marsan P., Russo V. A candidate gene association study for nine economically important traits in Italian Holstein cattle. Animal Genetics, 2014, vol. 45, no. 4, pp. 576–580. https://doi.org/10.1111/age.12164</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows / A. M. Clempson [et al.] // J. Dairy Sci. – 2011. – Vol. 94, № 7. – P. 3618–3628. https://doi.org/10.3168/JDS.2010-3626</mixed-citation><mixed-citation xml:lang="en">Clempson A. M., Pollott G. E., Brickell J. S., Bourne N. E., Munce N., Wathes D. C. Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows. Journal of Dairy Science, 2011, vol. 94, no. 7, pp. 3618–3628. https://doi.org/10.3168/JDS.2010-3626</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Genomic heritability and genome-wide association analysis of anti-Müllerian hormone in Holstein dairy heifers / M. Y. Nawaz [et al.] // J. Dairy Sci. – 2018. – Vol. 101, № 9. – P. 8063–8075. https://doi.org/10.3168/jds.2018-14798</mixed-citation><mixed-citation xml:lang="en">Nawaz M. Y., Jimenez-Krassel F., Steibel J. P., Lu Y., Baktula A., Vukasinovic N., Neuder L., Ireland J. L. H., Ireland J. J., Tempelman R. J. Genomic heritability and genome-wide association analysis of anti-Müllerian hormone in Holstein dairy heifers. Journal of Dairy Science, 2018, vol. 101, no. 9, pp. 8063–8075. https://doi.org/10.3168/jds.2018-14798</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Long-term changes in plasma anti-Müllerian hormone concentration and the relationship with superovulatory response in Japanese Black cattle / H. Hirayama [et al.] // J. Reprod. Dev. – 2017. – Vol. 63, № 1. – P. 95–100. https://doi.org/10.1262/jrd.2016-019</mixed-citation><mixed-citation xml:lang="en">Hirayama H., Naito A., Fukuda S., Fujii T., Asada M., Inaba Y., Takedomi T., Kawamata M., Moriyasu S., Kageyama S. Long-term changes in plasma anti-Müllerian hormone concentration and the relationship with superovulatory response in Japanese Black cattle. Journal of Reproduction and Development, 2017, vol. 63, no. 1, pp. 95–100. https://doi.org/10.1262/ jrd.2016-019</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Alward, K. J. Overview of Anti-Müllerian hormone (AMH) and association with fertility in female cattle / K. J. Alward, J. F. Bohlen // Reprod. Domest. Anim. – 2020. – Vol. 55, № 1. – P. 3–10. https://doi.org/10.1111/rda.13583</mixed-citation><mixed-citation xml:lang="en">Alward K. J., Bohlen J. F. Overview of Anti-Müllerian Hormone (AMH) and association with fertility in female cattle. Reproduction in Domestic Animals, 2020, vol. 55, no. 1, pp. 3–10. https://doi.org/10.1111/rda.13583</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Anti-Müllerian Hormone (AMH) and fertility management in agricultural species / F. Mossa [et al.] // Reproduction. – 2017. – Vol. 154, № 1. – P. R1–R11. https://doi.org/10.1530/REP-17-0104</mixed-citation><mixed-citation xml:lang="en">Mossa F., Jimenez-Krassel F., Scheetz D., Weber-Nielsen M., Evans A. C. O., Ireland J. J. Anti-Müllerian Hormone (AMH) and fertility management in agricultural species. Reproduction, 2017, vol. 154, no. 1, pp. R1–R11. https://doi.org/10.1530/REP17-0104</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Genetic diversity of DGAT1 gene linked to milk production in cattle populations of Ethiopia / B. Samuel [et al.] // BMC Genom. Data. – 2022. – Vol. 23, № 1. – Art. 64. https://doi.org/10.1186/s12863-022-01080-8</mixed-citation><mixed-citation xml:lang="en">Samuel B., Mengistie D., Assefa E., Kang M., Park C., Dadi H., Dinka H. Genetic diversity of DGAT1 gene linked to milk production in cattle populations of Ethiopia. BMC Genomic Data, 2022, vol. 23, no. 1, art. 64. https://doi.org/10.1186/ s12863-022-01080-8</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Association of DGAT1 with cattle, buffalo, goat, and sheep milk and meat production traits / M. Z. Khan [et al.] // Front. Vet. Sci. – 2021. – Vol. 8. – Art. 712470. https://doi.org/10.3389/fvets.2021.712470</mixed-citation><mixed-citation xml:lang="en">Khan M. Z., Ma Y., Ma J., Xiao J., Liu Y., Liu S., Khan A., Khan I. M., Cao Z. Association of DGAT1 with cattle, buffalo, goat, and sheep milk and meat production traits. Frontiers in Veterinary Science, 2021, vol. 8, art. 712470. https://doi.org/ 10.3389/fvets.2021.712470</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Evaluating markers in selected genes for association with functional longevity of dairy cattle / J. Szyda [et al.] // BMC Genet. – 2011. – Vol. 12. – Art. 30. https://doi.org/10.1186/1471-2156-12-30</mixed-citation><mixed-citation xml:lang="en">Szyda J., Morek-Kopeć M., Komisarek J., Zarnecki A. Evaluating markers in selected genes for association with functional longevity of dairy cattle. BMC Genetics, 2011, vol. 12, art. 30. https://doi.org/10.1186/1471-2156-12-30</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle / S. Nayeri [et al.] // J. Dairy Sci. – 2017. – Vol. 100, № 2. – P. 1246–1258. https://doi.org/10.3168/jds. 2016-11770.</mixed-citation><mixed-citation xml:lang="en">Nayeri S., Sargolzaei M., Abo-Ismail M. K., Miller S., Schenkel F., Moore S. S., Stothard P. Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle. Journal of Dairy Science, 2017, vol. 100, no. 2, pp. 1246–1258. https://doi.org/10.3168/jds.2016-11770</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">LEP and SCD polymorphisms are associated with milk somatic cell count, electrical conductivity and pH values in Holstein cows / J. Metin Kiyici [et al.] // Anim. Biotechnol. – 2019. – Vo. 31, № 6. – P. 498–503. https://doi.org/10.1080/ 10495398.2019.1628767</mixed-citation><mixed-citation xml:lang="en">Metin Kiyici J., Akyüz B., Kaliber M., Arslan K., Aksel E. G., Cinar M. U. LEP and SCD polymorphisms are associated with milk somatic cell count, electrical conductivity and pH values in Holstein cows. Animal Biotechnology, 2019, vol. 31, no. 6, pp. 498–503. https://doi.org/10.1080/10495398.2019.1628767</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Leptin as a nutritional signal regulating appetite and reproductive processes in seasonally breeding ruminants / D. A. Zieba [et al.] // J. Physiol. Pharmacol. – 2008. – Vol. 59, suppl. 9. – P. 7–18.</mixed-citation><mixed-citation xml:lang="en">Zieba D. A., Szczesna M., Klocek-Gorka B., Williams G. L. Leptin as a nutritional signal regulating appetite and reproductive processes in seasonally breeding ruminants. Journal of Physiology and Pharmacology, 2008, vol. 59, suppl. 9, pp. 7–18.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Траспов, А. А. Изучение полиморфизма митохондриальной ДНК крупного рогатого скота / А. А. Траспов, И. Ю. Долматова // Научное обеспечение инновационного развития АПК: материалы всерос. науч.-практ. конф. в рамках XX Юбилейн. специализир. выставки «АгроКомплекс-2010», 2–4 марта 2010 г. / Башк. гос. аграр. ун-т; редкол.: Р. Х. Авзалов, В. В. Гимранов. – Уфа, 2010. – Ч. 2. – С. 111–113.</mixed-citation><mixed-citation xml:lang="en">Traspov A. A., Dolmatova I. Yu. The study of polymorphism of mitochondrial DNA of cattle. Nauchnoe obespechenie innovatsionnogo razvitiya APK: materialy vserossiiskoi nauchno-prakticheskoi konferentsii v ramkakh XX Yubileinoi spetsializirovannoi vystavki “AgroKompleks-2010”, 2–4 marta 2010 g. [Scientific support of innovative development of agroindustrial complex: materials of the All-Russian scientific and practical conference within the framework of the XX Anniversary specialized exhibition “Agrocomplex-2010”, March 2–4, 2010]. Ufa, 2010, pt. 2, pp. 111–113 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Polymorphisms in the autosomal genes for mitochondrial function TFAM and UCP2 are associated with performance and longevity in dairy cows / A. M. Clempson [et al.] // Animal. – 2011. – Vol. 5, № 9. – Р. 1335–1343. https://doi.org/10.1017/ S1751731111000346</mixed-citation><mixed-citation xml:lang="en">Clempson A. M., Pollott G. E., Brickell J. S., Bourne N. E., Munce N., Wathes D. C. Polymorphisms in the autosomal genes for mitochondrial function TFAM and UCP2 are associated with performance and longevity in dairy cows. Animal, 2011, vol. 5, no. 9, pp. 1335–1343. https://doi.org/10.1017/S1751731111000346</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Association between single nucleotide polymorphism of rs1937 in TFAM gene and longevity among the elderly Chinese population: based on the CLHLS study / Q. Chen [et al.] // BMC Geriatr. – 2022. – Vol. 22, № 1. – Art. 16. https://doi.org/ 10.1186/s12877-021-02655-3</mixed-citation><mixed-citation xml:lang="en">Chen Q., Li Z.-H., Song W.-Q., Yao Y., Zhang Y.-J., Zhong W.-F., Zhang P.-D., Liu D., Zhang X.-R., Huang Q.-M., Zhao X.-Y., Shi X.-M., Mao C. Association between single nucleotide polymorphism of rs1937 in TFAM gene and longevity among the elderly Chinese population: based on the CLHLS study. BMC Geriatrics, 2022, vol. 22, no. 1, art. 16. https://doi.org/ 10.1186/s12877-021-02655-3</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Significant associations of the mitochondrial transcription factor A promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses / Z. Jiang [et al.] // Biochem. Biophys. Res. Commun. – 2005. – Vol. 334, № 2. – P. 516–523. https://doi.org/10.1016/j.bbrc.2005.06.120</mixed-citation><mixed-citation xml:lang="en">Jiang Z., Kunej T., Michal J., Gaskins Ch., Reeves J., Busboom J., Dovc P., Wright Jr. R. W. Significant associations of the mitochondrial transcription factor A promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses. Biochemical and Biophysical Research Communications, 2005, vol. 334, no. 2, pp. 516–523. https://doi.org/ 10.1016/j.bbrc.2005.06.120</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors / P. May-Panloup [et al.] // Reprod. Biol. Endocrinol. – 2005. – Vol. 3. – Art. 65. https://doi.org/10.1186/1477-7827-3-65</mixed-citation><mixed-citation xml:lang="en">May-Panloup P., Vignon X., Chrétien M. F., Heyman Y., Tamassia M., Malthièry Y., Reynier P. Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors. Reproductive Biology and Endocrinology, 2005, vol. 3, art. 65. https://doi.org/10.1186/1477-7827-3-65</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Echtay, K. S. Mitochondrial uncoupling proteins-what is their physiological role? / K. S. Echtay // Free Radic. Biol. Med. – 2007. – Vol. 43, № 10. – P. 1351–1371. https://doi.org/10.1016/j.freeradbiomed.2007.08.011</mixed-citation><mixed-citation xml:lang="en">Echtay K. S. Mitochondrial uncoupling proteins-what is their physiological role? Free Radical Biology and Medicine, 2007, vol. 43, no. 10, pp. 1351–7131. https://doi.org/10.1016/j.freeradbiomed.2007.08.011</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Курдеко, А. П. Особенности нарушений кальций-фосфорного обмена у лактирующих коров / А. П. Курдеко, Д. Д. Жерносеков, Г. Г. Пирханов // Актуальные вопросы ветеринарной медицины: материалы Междунар. науч. конф., посвящ. 100-летию каф. клин. диагностики, внутр. болезней животных им. Синева А.В., акушерства, 29–30 сент. 2022 г. / С.-Петерб. гос. ун-т ветеринар. медицины. – СПб., 2022. – С. 71–75.</mixed-citation><mixed-citation xml:lang="en">Kurdeko A. P., Zhernosekov D. D., Pirkhanov G. G. Features of calcium-phosphorus metabolism disorders in lactating cows. Aktual’nye voprosy veterinarnoi meditsiny: materialy Mezhdunarodnoi nauchnoi konferentsii, posvyashchennoi 100-letiyu kafedr klinicheskoi diagnostiki, vnutrennikh boleznei zhivotnykh im. Sineva A.V., akusherstva, 29–30 sentyabrya 2022 g. [Topical issues of veterinary medicine: materials of the International scientific conference, dedicated to the 100th anniversary of the Departments of Clinical Diagnostics, Internal Diseases of Animals named after Sineva A. V., Obstetrics, September 29–30, 2022]. St. Petersburg, 2022, pp. 71–75 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Polymorphisms and haplotypes in the bovine neuropeptide Y growth hormone receptor ghrelin insulin-like growth factor 2 and uncoupling proteins 2 and 3 genes and their associations with measures of growth performance feed efficiency and carcass merit in beef cattle / E. L. Sherman [et al.] // J. Anim. Sci. – 2008. – Vol. 86, № 1. – P. 1–16. https://doi.org/10.2527/ jas.2006-799</mixed-citation><mixed-citation xml:lang="en">Sherman E. L., Nkrumah J. D., Murdoch B. M., Li C., Wang Z., Fu A., Moore S. S. Polymorphisms and haplotypes in the bovine neuropeptide Y growth hormone receptor ghrelin insulin-like growth factor 2 and uncoupling proteins 2 and 3 genes and their associations with measures of growth performance feed efficiency and carcass merit in beef cattle. Journal of Animal Science, 2008, vol. 86, no. 1, pp. 1–16. https://doi.org/10.2527/jas.2006-799</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bauman, D. E. Effects of exogenous somatotropin on lactation / D. E. Bauman, R. G. Vernon // Ann. Rev. Nutr. – 1993. – Vol. 13. – P. 437–461. https://doi.org/10.1146/annurev.nu.13.070193.002253</mixed-citation><mixed-citation xml:lang="en">Bauman D. E., Vernon R. G. Effects of exogenous somatotropin on lactation. Annual Review of Nutrition, 1993, vol. 13, pp. 437–461. https://doi.org/10.1146/annurev.nu.13.070193.002253</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Abdolmohammadi, A. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle / A. Abdolmohammadi, P. Zamani // Gene. – 2014. – Vol. 540, № 1. – P. 92–95. https://doi.org/10.1016/j.gene.2014.02.011</mixed-citation><mixed-citation xml:lang="en">Abdolmohammadi A., Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene, 2014, vol. 540, no. 1, pp. 92–95. https://doi.org/10.1016/j.gene. 2014.02.011</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Москалев, А.А. Старение и гены / А.А. Москалев. – СПб.: Наука, 2008. – 358 c.</mixed-citation><mixed-citation xml:lang="en">Moskalev A. A. Aging and gene. St. Petersburg, Nauka Publ., 2008. 358 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models / D. E. Berryman [et al.] // Growth Horm. IGF Res. – 2008. – Vol. 18, № 6. – P. 455–471. https://doi.org/10.1016/j.ghir.2008.05.005</mixed-citation><mixed-citation xml:lang="en">Berryman D. E., Christiansen J. S., Johannsson G., Thorner M. O., Kopchick J. J. Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Hormone &amp; IGF Research, 2008, vol. 18, no. 6, pp. 455–471. https://doi.org/ 10.1016/J.Ghir.2008.05.005</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">A comparison of three strains of Holstein-Friesian cows grazed on pasture: growth, development, and puberty / K. A. Macdonald [et al.] // J. Dairy Sci. – 2007. – Vol. 90, № 8. – P. 3993–4003. https://doi.org/10.3168/jds.2007-0119</mixed-citation><mixed-citation xml:lang="en">Macdonald K. A., McNaughton L. R., Verkerk G. A., Penno J. W., Burton L. J., Berry D. P., Gore P. J., Lancaster J. A., Holmes C. W. A comparison of three strains of Holstein-Friesian cows grazed on pasture: growth, development, and puberty. Journal of Dairy Science, 2007, vol. 90, no. 8, pp. 3993–4003. https://doi.org/10.3168/jds.2007-0119</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Brickell, J. S. Effect of management factors and blood metabolites during the rearing period on growth in dairy heifers on UK farms / J. S. Brickell, M. M. McGowan, D. C. Wathes // Domest. Anim. Endocrinol. – 2009. – Vol. 36, № 2. – P. 67–81. https://doi.org/10.1016/j.domaniend.2008.10.005</mixed-citation><mixed-citation xml:lang="en">Brickell J. S., McGowan M. M., Wathes D. C. Effect of management factors and blood metabolites during the rearing period on growth in dairy heifers on UK farms. Domestic Animal Endocrinology, 2009, vol. 36, no. 2, pp. 67–81. https://doi.org/ 10.1016/j.domaniend.2008.10.005</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Wathes, D. C. Mechanisms linking metabolic status and disease with reproductive outcome in the dairy cow / D. C. Wathes // Reprod. Domest. Anim. – 2012. – Vol. 47, suppl. 4. – P. 304–312. https://doi.org/10.1111/j.1439-0531.2012.02090.x</mixed-citation><mixed-citation xml:lang="en">Wathes D. C. Mechanisms linking metabolic status and disease with reproductive outcome in the dairy cow. Reproduction in Domestic Animals, 2012, vol. 47, suppl. 4, pp. 304–312. https://doi.org/10.1111/j.1439-0531.2012.02090.x</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Role of insulin/insulin-like growth factor 1 signaling pathway in longevity / C. L. Cheng [et al.] // World J. Gastroenterol. – 2005. – Vol. 11, № 13. – P. 1891–1895. https://doi.org/10.3748/wjg.v11.i13.1891</mixed-citation><mixed-citation xml:lang="en">Cheng C. L., Gao T. Q., Wang Z., Li D. D. Role of insulin/insulin-like growth factor 1 signaling pathway in longevity. World Journal of Gastroenterology, 2005, vol. 11, no. 13, pp. 1891–1895. https://doi.org/10.3748/wjg.v11.i13.1891</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active / Y. Wang [et al.] // Mol. Biol. Cell. – 2011. – Vol. 22, № 9. – P. 1529–1538. https://doi.org/10.1091/mbc.E10-09-0785</mixed-citation><mixed-citation xml:lang="en">Wang Y., Cao H., Chen J., McNiven M. A. A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Molecular Biology of the Cell, 2011, vol. 22, no. 9, pp. 1529–1538. https://doi.org/ 10.1091/mbc.E10-09-0785</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies / E. Turro [et al.] // Sci. Transl. Med. – 2016. – Vol. 8, № 328. – Art. 328ra30. https://doi.org/ 10.1126/scitranslmed.aad7666</mixed-citation><mixed-citation xml:lang="en">Turro E., Greene D., Wijgaerts A., Thys C., Lentaigne C., Bariana T. K. (et al.). A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Science Translational Medicine, 2016, vol. 8, no. 328, art. 328ra30. https://doi.org/10.1126/scitranslmed.aad7666</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
